ROSE Trial
Sponsor: NIH-NINDS (U01 NS058634)
Project Description: This clinical trial, Radiosurgery or Open Surgery for Epilepsy, was designed to compare open surgery with radiosurgery in the treatment of patients with mesial temporal epilepsy. The trial was designed as a prospective randomized comparison of standard anterior temporal lobectomy vs. Gamma Knife radiosurgery for patients with mesial temporal lobe epilepsy. Patients are followed for a three-year period. Seizure remission between months 24-36 is the primary outcome measure. Secondary outcomes include neurocognitive outcomes (specifically, verbal memory for dominant hemisphere patients) as well as mood, function, quality of life, and cost.
Neuromodulation and Chronic Neural Electrical Stimulation
Sponsor: Institute for Engineering in Medicine
Project Description: Neuromodulation is a rapidly-growing field of study, encompassing a wide spectrum of implantable and non-invasive technology for the treatment of neurological and neuropsychiatric disorders. Faculty at the University of Minnesota are internationally recognized in several of these technologies, including deep brain stimulation (DBS), transcranial magnetic stimulation (TMS), and transcranial direct current stimulation (tDCS). Our long-term scientific goal is to develop a program project grant at the University of Minnesota to further develop computational tools and techniques that enable systems-level mapping of brain networks before and after neuromodulation therapies to identify predictors of response and optimal subject intervention parameters.
Dr. Henry was the site P.I. for the SANTE Trial, the results of which were reported in Epilepsia (Fisher R, Salanova V, Witt T, Worth R, Henry T, et al. Electrical stimulation of the anterior nucleus of thalamus for treatment of refractory partial epilepsy. Epilepsia 51: 899-908, 2010).